The representational distortion (RD) approach to similarity (e.g., Hahn, Chater, & Richardson, 2003) proposes that similarity is computed using the transformation distance between two entities. We argue that researchers who adopt this approach need to be concerned with how representational transformations can be determined a priori. We discuss several roadblocks to using this approach. Specifically we demonstrate the difficulties inherent in determining what transformations are psychologically salient and the importance of considering the directionality of transformations.

Mike Savage & Anne Witz, eds., Gender and Bureaucracy, Blackwells, Oxford, 1992, pp. 282, pb, £13.99, ISBN: 0631‐85283.

In recent years, there has been a particular emphasis placed on conducting randomized controlled trials (RCTs) that compare the relative efficacy of psychosocial and pharmacological interventions. This article addresses relevant ethical considerations in the conduct of these treatment trials, with a focus on RCTs with children. Ethical concerns, including therapeutic misconception, treatment preference, therapeutic equipoise, structure of treatments, and balancing risks versus benefits, are introduced through a clinical scenario and discussed as they relate to psychotherapy versus medication RCTs. In each (...) case, suggestions are made for researchers seeking to minimize the impact of these ethical concerns on research participants. (shrink)

Alienation and Connection addresses social constructs that perpetuate alienation through suffering. The contributors discuss how alienation through suffering in a variety of contexts can be transformed into connection and reconnection: human relationship with the environment, economic and social systems that disconnect and reconnect, cultural constructs that divide or can heal, encountered difference that brings opportunity, and various manifestations of personal pain that can be survived and even overcome.

Among philosophers of science there seems to be a general consensus that understanding represents a species of knowledge, but virtually every major epistemologist who has thought seriously about understanding has come to deny this claim. Against this prevailing tide in epistemology, I argue that understanding is, in fact, a species of knowledge: just like knowledge, for example, understanding is not transparent and can be Gettiered. I then consider how the psychological act of "grasping" that seems to be characteristic of understanding (...) differs from the sort of psychological act that often characterizes knowledge. Zagzebski's account Kvanvig's account Two problems Comanche cases Unreliable sources of information The upper-right quadrant So is understanding a species of knowledge? A false choice. (shrink)

I defend the claim that understanding is the goal of explanation against various persistent criticisms, especially the criticism that understanding is not truth-connected in the appropriate way, and hence is a merely psychological state. Part of the reason why understanding has been dismissed as the goal of explanation, I suggest, is because the psychological dimension of the goal of explanation has itself been almost entirely neglected. In turn, the psychological dimension of understanding—the Aha! experience, the sense that a certain explanation (...) “feels right”, and so on—has been conspicuously overemphasized. I try to correct for both of these exaggerations. Just as the goal of explanation includes a richer psychological—including phenomenological—dimension than is generally acknowledged, so too understanding has a stronger truth connection than is generally acknowledged.Keywords: Understanding; Explanation; Philosophy of science; Epistemology. (shrink)

I explore the extent to which the epistemic state of understanding is transparent to the one who understands. Against several contemporary epistemologists, I argue that it is not transparent in the way that many have claimed, drawing on results from developmental psychology, animal cognition, and other fields.

According to ‘orthodox’ epistemology, it has recently been said, whether or not a true belief amounts to knowledge depends exclusively on truth-related factors: for example, on whether the true belief was formed in a reliable way, or was supported by good evidence, and so on. Jason Stanley refers to this as the ‘intellectualist’ component of orthodox epistemology, and Jeremy Fantl and Matthew McGrath describe it as orthodox epistemology’s commitment to a ‘purely epistemic’ account of knowledge — that is, an account (...) of knowledge where only truth-related factors figure in whether or not a person knows. In the first part of this paper I try to clarify the intellectualist thesis and to distinguish what I take to be its two main strains. In the remainder of the paper I then take a more critical turn and argue that even if, as a matter of fact, traditional epistemology has endorsed intellectualism in both of its strains, this is a mistake on the part of the tradition. At least one way of understanding intellectualism should be rejected and its practicalist counterpart should be accepted instead. (shrink)

What is it that makes someone wise, or one person wiser than another? I argue that wisdom consists in knowledge of how to live well, and that this knowledge of how to live well is constituted by various further kinds of knowledge. One concern for this view is that knowledge is not needed for wisdom but rather some state short of knowledge, such as having rational or justified beliefs about various topics. Another concern is that the emphasis on knowing how (...) to live well fails to do justice to the ancient tradition of ‘theoretical wisdom’. I address both of these concerns in filling out the account. (shrink)

Defenders of pragmatic encroachment in epistemology (or what I call practicalism) need to address two main problems. First, the view seems to imply, absurdly, that knowledge can come and go quite easily—in particular, that it might come and go along with our variable practical interests. We can call this the stability problem. Second, there seems to be no fully satisfying way of explaining whose practical interests matter. We can call this the “whose stakes?” problem. I argue that both problems can (...) be addressed in roughly the same terms. More exactly, I argue that by first clarifying the whose stakes? problem an answer to the stability problem naturally falls out. (shrink)

Despite a recent surge of interest in philosophy as a way of life, it is not clear what it might mean for philosophy to guide one's life, or how a “philosophical” way of life might differ from a life guided by religion, tradition, or some other source. We argue against John Cooper that spiritual exercises figure crucially in the idea of philosophy as a way of life—not just in the ancient world but also today, at least if the idea is (...) to be viable. In order to make the case we attempt to clarify the nature of spiritual exercises, and to explore a number of fundamental questions, such as “What role does reason have in helping us to live well?” Here we distinguish between the discerning and motivational powers of reason, and argue that both elements have limitations as guides to living well. (shrink)

Explanatory inquiry characteristically begins with a certain puzzlement about the world. But why do certain situations elicit our puzzlement while others leave us, in some epistemically relevant sense, cold? Moreover, what exactly is involved in the move from a state of puzzlement to a state where one's puzzlement is satisfied? In this paper I try to answer both of these questions. I also suggest ways in which our account of scientific rationality might benefit from having a better sense of the (...) kind of epistemic goal we are trying to realize, when we engage in our explanatory inquiries. Two Senses The Need for Explanation An Example Proto-understanding Conclusion CiteULike Connotea Del.icio.us What's this? (shrink)

The sciences aim to get at the truth about the nature of the world. Do the humanities have a similar goal—namely, to get at the truth about things like novels, paintings, and historical events? I consider a few different ways in which the humanities aim at the truth about their objects, in the process giving rise to epistemic goods such as knowledge and understanding. Two works in the humanities are used as test cases: the historian Tyler Stovall’sParis Noir (1996) and (...) the musicologist Susan McClary’s article, ‘The Blasphemy of Talking Politics During Bach Year’ (1987). (shrink)

I try to return the focus of the philosophy of history to the nature of understanding, with a particular emphasis on Louis Mink’s project of exploring how historical understanding compares to the understanding we find in the natural sciences. On the whole, I come to a conclusion that Mink almost certainly would not have liked: that the understanding offered by history has a very similar epistemic profile to the understanding offered by the sciences, a similarity that stems from the fact (...) that both are concerned with grasping how the objects of their study are structured, or how the various elements of the things they study depend upon and relate to one another. At the same time, however, I claim that historical inquiry naturally puts us in a position to acquire further epistemic goods, including the old-fashioned epistemic good of wisdom, which is plausibly constituted by knowledge of how to live well. This is something the natural sciences cannot offer, and it is part of the reason why history is such an important form of inquiry. (shrink)

This paper offers and analysis of Ernest Sosa's Virtue Perspectivism. Although Sosa has been credited with fathering the influential contemporary movement known as Virtue Epistemology, I argue that Sosa imprudently abandons the reliabilist-based insights of Virtue Epistemology in favor of a reflection-based, "perspectival"' view. Sosa's mixed allegiance to reliabilist-based and reflection-based views of knowledge, in fact, leads to an unwelcome tension in his thought which can be relieved by recognizing that his reflection-based view is in fact an account of the (...) cognitive state of understanding, rather than an account of knowledge. Sosa makes matters difficult for himself because he expects too much, as it were, from the concept of knowledge, and in the process burdens his view with elements of reflection it does not require. To solve the problem, I suggest that Sosa needs to develop a two-tiered epistemology which recognizes that knowledge, on the one hand, and understanding, on the other, both have necessary and sufficient conditions unique to themselves. (shrink)

Abstract BACKGROUND: Anonymity remains the more common practice in gamete donations, but legislation prohibiting anonymity with a goal of protecting donor-conceived children's right to know their genetic origins is becoming more common. However, given the dearth of research investigating the function of anonymity for donors and recipients, it is unclear whether these policies will accomplish their goals. The aim of this study was to explore experiences with anonymity among oocyte donors and recipients who participated in an anonymous donor oocyte program (...) and to understand the ways in which anonymity functions for them. -/- METHODS: Semistructured interviews were conducted with 50 women: 28 oocyte donors and 22 recipients who were recruited from an academic center for reproductive medicine in the United States. -/- RESULTS: Donors and recipients view anonymity both as a mechanism to protect the interests of all parties (recipients, donors, and donor-conceived children) and as a point of conflict. Specifically, three key areas were identified where both donors and recipients saw anonymity as having an important role: relieving anxieties about family structures and obligations; protecting their interests and those of donor-conceived children (while acknowledging where interests conflict); and managing the future. -/- CONCLUSION: As gamete donation increasingly moves away from the practice of anonymity, examining why anonymity matters to stakeholders will be helpful in devising strategies to successfully implement identity-release options. (shrink)

ABSTRACTThis research investigated whether precues engage proactive control to reduce emotional interference during speech production. A picture-word interference task required participants to name target pictures accompanied by taboo, negative, or neutral distractors. Proactive control was manipulated by presenting precues that signalled the type of distractor that would appear on the next trial. Experiment 1 included one block of trials with precues and one without, whereas Experiment 2 mixed precued and uncued trials. Consistent with previous research, picture naming was slowed in (...) both experiments when distractors were taboo or negative compared to neutral, with the greatest slowing effect when distractors were taboo. Evidence that precues engaged proactive control to reduce interference from taboo distractors was found in Experiment 1. In contrast, mixing precued trials in Experiment 2 resulted in no taboo cueing benefit. These results suggest that item-level proactive control can b... (shrink)

Pothos suggests dispensing with the distinction between rules and similarity, without defining what is meant by either term. We agree that there are problems with the distinction between rules and similarity, but believe these will be solved only by exploring the representations and processes underlying cases purported to involve rules and similarity.

Despite the recent claims of some prominent Catholic philosophers, I argue that Cardinal Newman's writings are in fact largely compatible with the contemporary movement in the philosophy of religion known as Reformed Epistemology, and in particular with the work of Alvin Plantinga. I first show how the thought of both Newman and Plantinga was molded in response to the "evidentialist" claims of John Locke. I then examine the details of Newman's response, especially as seen in his Essay in Aid of (...) A Grammar of Assent, suggesting that many of Newman's central ideas closely mirror Plantinga's. Finally, I argue that ifNewman and Plantinga part ways at any point, it is with respect to the basicality of specifically Christian (as opposed to theistic) belief. (shrink)

This ground-breaking book opens up new vistas on the study of the humanities. Co-authored by three philosophers, it offers an in-depth exploration of a range of questions. For example, what, if anything, unifies scholarship in the humanities? Is it possible to attain objective truth in fields like history or literary studies or philosophy, or is everything a matter of perspective or standpoint? It is possible for fields in the humanities to make progress, and if so, how? And what should we (...) make of the political aims of the humanities-for example, the desire by many scholars in the humanities to uncover systems of oppression and domination? Does this interfere with "objective" scholarship or not? A host of new topics are also considered, such as whether or not replication studies are possible and worthwhile in the context of the humanities, and whether deference to other scholars is legitimate in the humanities. Finally, new "case studies" are introduced that look at how fields such as history, literary studies, and musicology advance our understanding of their topics, and a provocative set of new "rules" for interpretation in the humanities are proposed. (shrink)

Several critics have denied value incommensurability – or the claim, roughly, that there is no common measure in terms of which values can be weighed – on the basis of what we might call the argument from easy cases. Although the argument from easy cases is quite popular, what is much less often discussed is what exactly the argument entails – in other words, what sort of further commitments the argument generates. Suppose we grant that easy cases point to the (...) existence of a common measure. How then should we think about this common measure? What is its scope? How widely does it range? I attempt to clarify these questions and in the process evaluate the force of the argument from easy cases. (shrink)

In this paper I consider the challenge to rational choice posed by the problem of value incommensurability, and argue that incommensurabilists misrepresentour position as practical reasoners. In essence, I claim that reason has considerably more to work with than their arguments suggest, and that as a result it is possible for us to compare even the deepest values. To say that it is possible for us to compare values is not to say that it is always easy, however, or that (...) thequestion of how best to characterize the common measure that allows for these comparisons isn’t open to vigorous dispute. But I argue that it is one thing to saythat the measure is obscure or that it guides us only imprecisely—and quite another to claim that it is conceptually impossible to weigh the deep values in lightof a common standard. (shrink)

Explanatory inquiry characteristically begins with a certain puzzlement about the world. But why do certain situations elicit our puzzlement while others leave us, in some epistemically relevant sense, cold? Moreover, what exactly is involved in the move from a state of puzzlement to a state where one’s puzzlement is satisfied? In this paper I try to make sense of these questions by focusing on two case studies, one from the popular literature on string theory and one from recent debates in (...) the philosophy of mind. (shrink)

Truth monism is the idea that only true beliefs are of fundamental epistemic value. The present paper considers three objections to truth monism, and argues that, while the truth monist has plausible responses to the first two objections, the third objection suggests that truth monism should be reformulated. On this reformulation, which we refer to as accuracy monism, the fundamental epistemic goal is accuracy, where accuracy is a matter of “getting it right.” The idea then developed is that accuracy is (...) a genus with several species. Believing truly is a prominent species, but it is not the only one. Finally, it is argued that accuracy monism is equally good or better than both traditional truth monism and its main dialectical rival, value pluralism, when it comes to satisfying three important axiological desiderata. (shrink)

This essay presents an account of what it takes to live a philosophical way of life: practitioners must be committed to a worldview, structure their lives around it, and engage in truth‐directed practices. Contra John Cooper, it does not require that one’s life be solely guided by reason. Religious or tradition‐based ways of life count as truth directed as long as their practices are reasons responsive and would be truth directed if the claims made by their way of life are (...) correct. The essay argues that these three conditions can be met by progressors as well as sages. Making progress in how one acts in the world, and improving one’s understanding and direction through being part of a community is living a philosophical way of life. The offered view acknowledges more ways to develop the art of living and enables a broader range of people to count as living philosophically. (shrink)

Johanna Knapstein,1 Daniel Grimm,1 Marcus A Wörns,1 Peter R Galle,1 Hauke Lang,2 Tim Zimmermann111st Department of Internal Medicine, Johannes Gutenberg-University, Mainz, Germany; 2Department of General, Visceral and Transplantation Surgery, Johannes Gutenberg-University, Mainz, GermanyIntroduction: Hepatitis C virus reinfection occurs universally after liver transplantation, with accelerated cirrhosis rates of up to 30% within 5 years after liver transplantation. Dual antiviral therapy with pegylated interferon-2a and ribavirin only reaches sustained virological response rates of ~30% after liver transplantation. With the approval of viral (...) NS3/4A protease inhibitors telaprevir, boceprevir, and simeprevir and the NS5B polymerase inhibitor sofosbuvir, combination therapy offers new therapeutic options for HCV-infected patients, resulting in considerably higher sustained virological response rates in the nontransplant setting. Case presentation: We report three cases of TVR-based triple antiviral therapy in HCV genotype 1 reinfected patients after liver transplantation, of whom a 57-year-old Caucasian female and a 43-year-old Caucasian male were therapy naïve, and a 49-year-old Caucasian male patient was pretreated ineffectively. After 4 weeks of therapy, viral load decreased one to three log10 and became negative in weeks 6 to 8 in the therapy naïve patients. The pretreated patient showed a negative viral load in week 4. TVR was administered over 12 weeks, 750 mg thrice daily. Doses of immunosuppression with cyclosporine were reduced four to six fold. Initial peg-IFN and RBV doses ranged from 135–180 µg/week and 800–1,200 mg/day, according to the patient's body weight. Doses of peg-IFN and RBV were adapted to 90–135 µg/week and 400–800 mg/day after 2 to 12 weeks of protease inhibitor therapy. Dual therapy was continued for 36 weeks with total treatment duration of 48 weeks in the therapy naïve patients leading to a sustained virological response 12 weeks after the end of therapy. In the pretreated patient a breakthrough was detected in week 24 and therapy was discontinued. Overall, antiviral therapy was well tolerated. Side effects included dysgeusia and anemia leading to erythropoietin application and blood transfusions. Conclusion: This case series emphasizes that triple therapy with TVR is an efficient treatment for therapy naïve HCV genotype 1 reinfected patients after liver transplantation. But therapeutic options for pretreated patients require improvement. Keyword: cyclosporine, interferon, ribavirin, hepatitis C, protease inhibitor. (shrink)